Inhibition of the activity of pro-inflammatory secretory phospholipase A2by acute phase proteins

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منابع مشابه

Inhibition of the activity of pro-inflammatory secretory phospholipase A2 by acute phase proteins

Pro-Inflammatory non-pancreatic phospholipase A(2) (sPLA(2)) is markedly over-expressed in acute systemic and chronic local inflammatory processes. Since in acute phase reaction sPLA(2) is often over-expressed simultaneously with acute phase proteins (APP), it is important to determine whether APP interacts with sPLA(2). We tested ten APPs for interaction with sPLA(2) using as a substrate multi...

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Secretory phospholipase A2 in the pathogenesis of acute dengue infection

INTRODUCTION Platelet activating factor (PAF) is an important mediator of vascular leak in acute dengue. Phospholipase A2s (PLA2) are inflammatory lipid enzymes that generate and regulate PAF and other mediators associated with mast cells. We sought to investigate if mast cell activation and increases in secretory sPLA2s are associated with an increase in PAF and occurrence of dengue haemorrhag...

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ژورنال

عنوان ژورنال: Mediators of Inflammation

سال: 1996

ISSN: 0962-9351,1466-1861

DOI: 10.1155/s0962935196000270